irremediable
词根词缀：
irrigate v. 灌溉
ir 向内，进入 + rig 浇水 + ate 做，造成，使… → 让水进入 → 灌溉
irrupt v. 闯入
ir 向内，进入 + rupt 断 → 打断进入 → 闯入
irruption n. 闯入
irrupt的名词
irradiate v. 照射
ir 表加强 + radi 光线，辐射 + ate 做，造成，使… → 照射
irritate v. 激怒；刺激
ir 表加强 + rit 擦 + ate 做，造成，使… → 摩擦 → 激怒
数据来源：新东方英语词汇速记大全
相关例句：
As we release the desire of material, not can we sacrifice the moral cultivation and spiritual promotion, otherwise, the action which is taking a drastic measure to deal with a situation, will caused a catastrophic and irremediable lose to the society sooner or later.
现代人的物欲的释放，决不能以牺牲人的道德修养和精神境界的提升为代价，否则，这种釜底抽薪之举，迟早会对社会造成难以弥补的灾难性损失。
But in resent years, the overexploitation of tourism makes many ecotourism destination turn "sunlight industry" into the road of destructively development and construction which even leads irremediable loss.
但近年来，旅游业的过度开发，使很多的生态旅游地从阳光产业走向了破坏性开发建设的道路，有些甚至造成了不可挽回的损失。
The engineering practice shows that structural failure caused by the invalidation of prestressing tendon is irremediable.
工程实践表明，由预应力筋失效造成的结构破坏是不可挽救的。
Such increase has caused irremediable damages to the domestic industry;
此种增加对国内产业造成难以补救的损害；
But the weakening of the English seemed irremediable.
但是英军的困惫看来是无可救药的。
The evil is now irremediable.
这种不幸现在是无法补救了。